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spoIIT [2017-07-25 10:39:20]
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spoIIT [2017-07-25 10:39:20]

co-activator (with SpoIIR) for triggering SpoIIGA-dependent processing of SigE
locus
BSU36770
pI
6.88
mw
28.48 kDa
protein length
246 aa Sequence Blast
gene length
738 bp Sequence Blast
function
control of SigE processing and activation
product
co-activator (with SpoIIR) for triggering SpoIIGA-dependent processing of SigE
essential
no
synonyms
ywmB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other]

    • Gene

    Coordinates
    3,779,293 → 3,780,033

    Phenotype of a mutant

  • mild sporulation defect due to inefficient activation of [protein|3CB24D493B3282278B7DC61CE3C793DFA815F9E2|SigE] [Pubmed|26735940]
  • inactivation of ''[gene|3A8E0417C4EC85FDDE1178B775F6579C8F1009C6|spoIIT]'' reduces sporulation efficiency to 38% that of wild type cells; abortively disporic [Pubmed|26735940]

    • The protein

    Structure

  • [PDB|2FPN]

    • [SW|Localization]

  • secreted from the forespore to the intermembrane space between the forespore and the mother cell [Pubmed|26735940]

    • Expression and Regulation

    Operons

    genes
    [gene|32CE4F77F08F926152BECAB56E2841E1FFB27600|ywzB]-[gene|3A8E0417C4EC85FDDE1178B775F6579C8F1009C6|spoIIT]-[gene|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA]
    description
    [Pubmed|22383849]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|22383849], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF]: sigma factor, [Pubmed|26735940], in [regulon|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF regulon]

    • regulation

  • expressed early during sporulation in the forespore ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF]) [Pubmed|26735940]
    • view in new tab

    genes
    [gene|3A8E0417C4EC85FDDE1178B775F6579C8F1009C6|spoIIT]-[gene|DA763F7C2192655C590752C2A285ADF902B11BCA|murAA]
    description
    [Pubmed|26735940]

    regulation

  • expressed early during sporulation in the forespore ([protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF]) [Pubmed|26735940]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-A189 (ywmB::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/189 NBRP B. subtilis, Japan]

    • References

  • 26735940,22383849,26735940